Fig 1: ROC curves and the area under curve (AUC) with confidence interval (CI) of ATG5 (A), HMGB1 (B), miR-126 (C), miR-222 (D), Mesothelin (E). Cut-offs, sensitivity and specificity are shown (F). ROC curve and AUC estimation of the logit model with ATG5 and age using the dataset to discriminate the asbestos-exposed subjects from asbestos-exposed subjects with malignancy (G). Differences with p < 0.05 are statistically significant
Fig 2: Distribution of biomarkers in the study groups. Serum levels of ATG5, HMGB1, miR-126, miR-222 and Mesothelin in healthy controls (Ctrl), asbestos-exposed subjects (Exp), pre-diagnostic samples, and malignant pleural mesothelioma (MPM) patients. Comparisons among groups were determined by one-way ANOVA with Tukey post hoc analysis. Differences with p < 0.05 are statistically significant
Fig 3: Kaplan-Meier survival curves for e-MPM stratified for the biomarkers. Low and high levels of ATG5 (A), HMGB1 (B), miR-126 (C), miR-222 (D) and Mesothelin (E) were associated with overall survival (OS). Comparisons between groups were made using log-rank test, and two-sided p < 0.05 was considered statistically significant
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